If you are using the SPiceX method for updating standard expansion boards (XBIO16, XIRO16, FP16, HIO16, MBIO16), you somehow need to prevent the controller from trying to also perform “normal” I/O updates (which would conflict with what you are trying to do). Here are the rules for how this is handled with standard expansion boards:

• SPiceX can only be used if there are more than 64 XPice I/Os (4 XBIO16 boards or 8 XIRO16/HIO16 boards or equivalent). If SPLat/PC recognizes and configures itself to the expanded configuration, it won’t work in SPiceX mode.
• Executing an SPxTxfrU or SPxMode instruction will switch the board to SPiceX mode only if the previous condition is met.
• Inputs are inverted, i.e. an ON input becomes a logical 0/False in RAM
• Connecting to SPLat/PC after SPiceX mode is enabled will turn off SPiceX mode improperly. If there are 64 or fewer XPice I/Os SPLat/PC will show them as regular I/O but attempting to activate them from the SPLat/PC screen may produce erroneous results.